产品货号：
Z22062
中文名称：
NKG2D/KLRK1抗体
英文名称：
Anti-NKG2D/KLRK1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NKG2D/KLRK1 Antibody |
| 指标别名 | killer cell lectin like receptor K1;CD314;D12S2489E;KLR;NKG2-D;NKG2D;KLRK1 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB |
| 基因名称 | KLRK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human NKG2D (YQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYH). |
| 实际分子量 | 25KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NKG2D is encoded by KLRK1 gene which is located in the NK-gene complex (NKC) situated on and chromosome 12 in humans.Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation.They can also regulate specific humoral and cell-mediated immunity.NK cells preferentially express several calcium-dependent (C-type) lectins,which have been implicated in the regulation of NK cell function.The NKG2 gene family is located within the NK complex,a region that contains several C-type lectin genes preferentially expressed in NK cells.This gene encodes a member of the NKG2 family.The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain.It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins,where ligand-receptor interactions can result in the activation of NK and T cells.The surface expression of these ligands is important for the recognition of stressed cells by the immune system,and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers.Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C,member 4) family member in the same cluster. |
| Uniprot ID | P26718 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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